Application of Algebraic Topology to Homologous Recombination of DNA
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چکیده
منابع مشابه
Functions of homologous DNA recombination
Homologous DNA (or genetic) recombination plays important roles in heredity and evolution. A recent study has shown that a physical linkage established by recombination between two or more homologous DNA regions or molecules is essential for the precise disjunction of homologous chromosomes in meiosis and the recovery of collapsed DNA replication forks. These physical linkages in recombination ...
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DNA Assembly Technologies Based on Homologous Recombination
The origins of the recombinant DNA technology can be traced back to the discovery of restriction enzymes and the generation of the first recombinant DNA molecule over 40 years ago (1–3). Since then, and with the emergence of PCR, scientists have generated a number of elegant cloning systems that enable the manipulation of DNA fragments in various ways (for recent reviews see Refs 4–7). Some rem...
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Homologous recombination (HR) is a central process to ensure genomic stability in somatic cells and during meiosis. HR-associated DNA synthesis determines in large part the fidelity of the process. A number of recent studies have demonstrated that DNA synthesis during HR is conservative, less processive, and more mutagenic than replicative DNA synthesis. In this review, we describe mechanistic ...
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ژورنال
عنوان ژورنال: iScience
سال: 2018
ISSN: 2589-0042
DOI: 10.1016/j.isci.2018.05.008